Blar i forfatter "Cuminetti, Vincent"

Viser treff 1-4 av 4

    • Bone Marrow Adipocytes: The Enigmatic Components of the Hematopoietic Stem Cell Niche 

      Cuminetti, Vincent; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-18)
      Bone marrow adipocytes (BMA) exert pleiotropic roles beyond mere lipid storage and filling of bone marrow (BM) empty spaces, and we are only now beginning to understand their regulatory traits and versatility. BMA arise from the differentiation of BM mesenchymal stromal cells, but they seem to be a heterogeneous population with distinct metabolisms, lipid compositions, secretory properties and ...

    • Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells 

      Vilaplana-Lopera, Nuria; Cuminetti, Vincent; Almaghrabi, Ruba; Papatzikas, Grigorios; Rout, Ashok Kumar; Jeeves, Mark; González, Elena; Alyahyawi, Yara; Cunningham, Alan; Erdem, Ayşegül; Schnütgen, Frank; Raghavan, Manoj; Potluri, Sandeep; Cazier, Jean-Baptiste; Schuringa, Jan Jacob; Reed, Michelle AC; Arranz, Lorena; Günther, Ulrich L; Garcia, Paloma (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-02)
      Acute myeloid leukaemia (AML) cells interact and modulate components of their surrounding microenvironment into their own benefit. Stromal cells have been shown to support AML survival and progression through various mechanisms. Nonetheless, whether AML cells could establish beneficial metabolic interactions with stromal cells is underexplored. By using a combination of human AML cell lines and AML ...

    • Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation 

      Villatoro, Alicia; Cuminetti, Vincent; Bernal, Aurora; Torroja, Carlos; Cossío, Itziar; Benguría, Alberto; Ferré, Marc; Konieczny, Joanna; Vázquez, Enrique; Rubio, Andrea; Utnes, Peter Andree; You, Xiaona; Fenton, Christopher Graham; Paulssen, Ruth H; Zhang, Jing; Sánchez-Cabo, Fatima; Dopazo, Ana; Vik, Anders; Anderssen, Endre; Hidalgo, Andres; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-03)
      Here we explored the role of interleukin-1β (IL-1β) repressor cytokine, IL-1 receptor antagonist (IL-1rn), in both healthy and abnormal hematopoiesis. Low IL-1RN is frequent in acute myeloid leukemia (AML) patients and represents a prognostic marker of reduced survival. Treatments with IL-1RN and the IL-1β monoclonal antibody canakinumab reduce the expansion of leukemic cells, including CD34+ ...

    • Leukemia Stem Cell Release From the Stem Cell Niche to Treat Acute Myeloid Leukemia 

      Villatoro, Alicia; Konieczny, Joanna; Cuminetti, Vincent; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-09)
      Acute myeloid leukemia (AML) is a heterogeneous, complex, and deadly disease, whose treatment has hardly evolved for decades and grounds on the use of intensive chemotherapy regimens. Chemotherapy helps reduce AML bulk, but promotes relapse in the long-run by selection of chemoresistant leukemia stem cells (LSC). These may diversify and result in progression to more aggressive forms of AML. <i>In ...